{"id":40661,"date":"2018-01-30T10:12:47","date_gmt":"2018-01-30T10:12:47","guid":{"rendered":"http:\/\/raed.academy\/?p=40661"},"modified":"2018-01-31T16:44:01","modified_gmt":"2018-01-31T16:44:01","slug":"nanotecnologia-contra-el-cancer","status":"publish","type":"post","link":"https:\/\/raed.academy\/ca\/nanotecnologia-contra-el-cancer\/","title":{"rendered":"Nanotecnologia contra el c\u00e0ncer"},"content":{"rendered":"

Les nanoc\u00e0psules i les nanopart\u00edcules radiosensibilitzants permetran optimitzar la lluita contra les c\u00e8l\u00b7lules cancer\u00edgenes minimitzant els efectes sobre les c\u00e8l\u00b7lules sanes<\/h2>\n

Ferran Guedea<\/strong><\/a>, catedr\u00e0tic d’Oncologia Radioter\u00e0pica de la Universitat de Barcelona<\/strong><\/a>, \u200b\u200bdirector d’Oncologia Radioter\u00e0pica de l’Institut Catal\u00e0 d’Oncologia<\/strong><\/a> i acad\u00e8mic de n\u00famero de la Reial Acad\u00e8mia Europea de Doctors-Barcelona 1914<\/strong> (RAED) ha realitzat al costat de la especialista In\u00e9s Guix<\/strong> l’estudi “Nanotecnolog\u00eda frente al c\u00e1ncer”<\/strong>, que ser\u00e0 publicat al proper n\u00famero de Tribuna Plural<\/strong>, la revista cient\u00edfica de la RAED.<\/p>\n

Guedea i Guix incideixen en dos aspectes de la nanomedicina que ja s’han demostrat efectius en la lluita contra el c\u00e0ncer: les nanoc\u00e0psules per a l’administraci\u00f3 de f\u00e0rmacs i les nanopart\u00edcules radiosensibilitzants, que se sumen a altres aplicacions de la nanotecnologia i nanomedicina en desenvolupament com ara els nanorobots , la fototer\u00e0pia, els nanomaterials per al c\u00e0lcul de dosimetries in vivo o les nanopart\u00edcules presentadores d’ant\u00edgens. Els estudiosos assenyalen com els f\u00e0rmacs cl\u00e0ssics que es fan servir a la quimioter\u00e0pia, un cop arriben al torrent sanguini, es distribueixen sist\u00e8micament per tot el cos i, en lloc d’atacar exclusivament al tumor, tamb\u00e9 fan mal a les c\u00e8l\u00b7lules sanes que m\u00e9s proliferen. Les nanoc\u00e0psules, per\u00f2, aconsegueixen administrar els agents quimioter\u00e0pics en major quantitat a les c\u00e8l\u00b7lules neopl\u00e0siques que a les sanes, reduint d’aquesta manera enormement la seva toxicitat.<\/p>\n

\"Dr.

Dr. Ferran Guedea Edo<\/p><\/div>\n

“Les estrat\u00e8gies que s’empren per crear els anomenats nanocarriers selectius, capa\u00e7os d’actuar espec\u00edficament sobre les c\u00e8l\u00b7lules cancer\u00edgenes, s\u00f3n m\u00faltiples i molt diverses. Algunes nanoc\u00e0psules estan recobertes d’anticossos enfront d’ant\u00edgens tumorals, de manera que \u00fanicament s’adhereixen i s\u00f3n endocitades per les c\u00e8l\u00b7lules neopl\u00e0siques que ho expressen. Altres nanocarriers s\u00f3n quimiosensibles al pH o la temperatura i, en entrar en contacte amb mitjans \u00e0cids que superen els 38\u00baC, el que constitueix una caracter\u00edstica diferencial t\u00edpica dels microambients tumorals, es fragmenten i alliberen el f\u00e0rmac actiu. Aix\u00ed mateix , s’han dissenyat nanoc\u00e0psules capaces de respondre a ultrasons de tal manera que, en aplicar-los sobre la zona del cos on s’assenta el tumor, a la superf\u00edcie dels nanocarriers es formen porus que permeten la sortida de l’agent quimioter\u00e0pic en aquesta localitzaci\u00f3”, assenyala l’estudi.<\/p>\n

La radioter\u00e0pia, per la seva banda, tampoc aconsegueix evitar danyar tamb\u00e9 als \u00f2rgans sans malgrat que les c\u00e8l\u00b7lules cancer\u00edgenes s\u00f3n m\u00e9s fotosensibles. En aquest terreny, les nanopart\u00edcules radiosensibilitzants, formades per pol\u00edmers d’elements amb un elevat nombre at\u00f2mic, aconsegueixen ampliar enormement la finestra terap\u00e8utica de la radioter\u00e0pia i es fixen a les c\u00e8l\u00b7lules cancer\u00edgenes igual que les nanoc\u00e0psules. Guedea i Guix tamb\u00e9 apunten als nanorobots com un mecanisme de futur capa\u00e7 de millorar exponencialment la lluita contra el c\u00e0ncer.<\/p>\n

Fotograf\u00eda: Representaci\u00f3 tridimensional de dues nanoc\u00e1psules. Fonts: BIND Therapeutics, Harvard Medical School y Digizyme Inc.; Centre National de la Recherche Scientifique (CNRS)<\/div>\n","protected":false},"excerpt":{"rendered":"

Les nanoc\u00e0psules i les nanopart\u00edcules radiosensibilitzants permetran optimitzar la lluita contra les c\u00e8l\u00b7lules cancer\u00edgenes minimitzant els efectes sobre les c\u00e8l\u00b7lules sanes Ferran Guedea, catedr\u00e0tic d’Oncologia Radioter\u00e0pica de la Universitat de Barcelona, \u200b\u200bdirector d’Oncologia Radioter\u00e0pica de l’Institut Catal\u00e0 d’Oncologia i acad\u00e8mic de n\u00famero de la Reial Acad\u00e8mia Europea de Doctors-Barcelona 1914 (RAED) ha realitzat al costat […]<\/p>\n","protected":false},"author":12,"featured_media":40561,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[72],"tags":[],"class_list":["post-40661","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uncategorized-ca","et-has-post-format-content","et_post_format-et-post-format-standard"],"yoast_head":"\nNanotecnologia contra el c\u00e0ncer - Reial Acad\u00e8mia Europea de Doctors<\/title>\n<meta name=\"description\" content=\"Ferran Guedea ha realitzat al costat de In\u00e9s Guix l'estudi "Nanotecnolog\u00eda frente al c\u00e1ncer". 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