{"id":151755,"date":"2024-07-12T10:16:05","date_gmt":"2024-07-12T10:16:05","guid":{"rendered":"https:\/\/raed.academy\/?p=151755"},"modified":"2024-07-12T10:16:05","modified_gmt":"2024-07-12T10:16:05","slug":"els-riscos-de-la-melatonina","status":"publish","type":"post","link":"https:\/\/raed.academy\/ca\/els-riscos-de-la-melatonina\/","title":{"rendered":"Els riscos de la melatonina"},"content":{"rendered":"
\"Francisco

Dr. Francisco L\u00f3pez Mu\u00f1oz<\/p><\/div>\n

Francisco L\u00f3pez Mu\u00f1oz<\/strong><\/em><\/a>, catedr\u00e0tic de Farmacologia i vicerector de Recerca, Ci\u00e8ncia i Doctorat de la Universitat Camilo Jos\u00e9 Cela<\/strong>, membre fundador del Comit\u00e8 d’Observaci\u00f3<\/strong> de l’Observatori de Drets Humans d’Espanya<\/strong> i acad\u00e8mic de n\u00famero de la Reial Acad\u00e8mia Europea de Doctors-Barcelona 1914<\/strong> (RAED), va publicar el 3 de juliol passat al diari digital El Espa\u00f1ol<\/strong> l’article “Los tres peligros de la melatonina: un f\u00e1rmaco vendido como suplemento alimenticio en Espa\u00f1a”<\/strong>, que firma juntament amb Alejandro Romero <\/strong>i Eva Ramo<\/strong>s, professors de Toxicologia de la Universitat Complutense de Madrid<\/strong>, i Antonio Juber\u00edas<\/strong>, farmac\u00e8utic i tamb\u00e9 docent universitari.<\/p>\n

Els quatre experts inicien la seva argumentaci\u00f3 assenyalant que si b\u00e9 nombrosos estudis han documentat la baixa toxicitat de la melatonina en un ampli rang de dosi, sense evidenciar efectes adversos greus o d’import\u00e0ncia cl\u00ednica significativa, manca informaci\u00f3 concloent sobre la seva toxicitat cr\u00f2nica, el seu impacte a les poblacions espec\u00edfiques i la interacci\u00f3 amb altres medicaments. “El concepte de la seguretat absoluta de la melatonina no s’alinea amb la varietat de sistemes fisiol\u00f2gics que afecta. Aquesta associaci\u00f3 explicaria la profusi\u00f3 d’estudis sobre la seva aplicaci\u00f3 en patologies diverses, inclosa la Covid-19, tot i que sense resultats ferms en molts d’ells”, assenyalen.<\/p>\n

La seva condici\u00f3 de medicament destinat a tractar malalties rares per part de l’Ag\u00e8ncia Europea del Medicament<\/strong> fa augmentar les indicacions basades en models experimentals: asf\u00edxia i retinopatia perinatals, preecl\u00e0mpsia, retinitis pigmentosa, s\u00edndrome radioactiu agut, hemorr\u00e0gia intracerebral no traum\u00e0tica o enterocoliti signants. “La seva autoritzaci\u00f3 per part d’aquesta ag\u00e8ncia com a inductor del son ha despertat inter\u00e8s sobre els possibles efectes secundaris en nens i el seu \u00fas prolongat. S’ha reconegut que no hi ha estudis s\u00f2lids que n’avalin la seguretat a llarg termini a la poblaci\u00f3 infantil, en dones embarassades oa dosis elevades”, afegeixen.<\/p>\n

\"\"La situaci\u00f3 \u00e9s diferent als Estats Units, on l’Ag\u00e8ncia Federal d’Aliments i Medicaments<\/strong> no considera la melatonina un f\u00e0rmac. “Aix\u00f2 no impedeix, que la mateixa ag\u00e8ncia adverteixi sobre els possibles efectes adversos de la seva administraci\u00f3 per a trastorns del son, com a problemes amb els ritmes circadians i insomni, a causa de la falta d’estudis concloents sobre la seva toxicitat a llarg termini”, expliquen els autors, alertant que la seguretat i efic\u00e0cia del principi actiu es poden veure compromeses, especialment en les formes comercials de venda lliure, si inclouen la substituci\u00f3 de principis actius, la pres\u00e8ncia de contaminants i subst\u00e0ncies no desitjades, una elaboraci\u00f3 que no compleixi amb les bones pr\u00e0ctiques de fabricaci\u00f3 i un etiquetatge que no garanteixi la dosi real i est\u00e0ndard de qualitat. Un fet especialment rellevant at\u00e8s l’\u00fas habitual en nens d’aquest principi actiu.<\/p>\n

Reconegut divulgador de la hist\u00f2ria contempor\u00e0nia, la literatura espanyola dels Segles d’Or i la medicina i farmacologia, L\u00f3pez Mu\u00f1oz \u00e9s doctor en Medicina i Cirurgia i doctor en Llengua i Literatura Espanyoles, especialista en Medicina Farmac\u00e8utica i diplomat en Estudis sobre l’Holocaust per l’Escola Internacional per als Estudis de l’Holocaust<\/strong> de Iad Vaixem, a Jerusalem. \u00c9s investigador de l’Institut de Recerca Hospital 12 d’Octubre<\/strong> de Madrid. Ha participat en nombroses investigacions i \u00e9s autor de monografies i articles a les seves \u00e0rees de recerca.<\/p>\n

Llegiu l’article<\/a><\/h2>\n","protected":false},"excerpt":{"rendered":"

Francisco L\u00f3pez Mu\u00f1oz publica l’article “Los tres peligros de la melatonina: un f\u00e1rmaco vendido como suplemento alimenticio en Espa\u00f1a”, el qual signa juntament amb Alejandro Romero Mart\u00ednez, Eva Ramos, i Antonio Juber\u00edas<\/p>\n","protected":false},"author":12,"featured_media":123953,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[455,442,213],"tags":[],"class_list":["post-151755","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ciencies-de-la-salut","category-ciencies-farmaceutiques-ciencies-de-la-salut","category-medicina-i-cirurgia","et-has-post-format-content","et_post_format-et-post-format-standard"],"yoast_head":"\nEls riscos de la melatonina - Reial Acad\u00e8mia Europea de Doctors<\/title>\n<meta name=\"description\" content=\"Francisco L\u00f3pez Mu\u00f1oz publica l'article "Los tres peligros de la melatonina: un f\u00e1rmaco vendido como suplemento alimenticio en Espa\u00f1a"\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/raed.academy\/ca\/els-riscos-de-la-melatonina\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Els riscos de la melatonina - 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