Carol Moreno<\/strong><\/em><\/a>.<\/p>\nEl nou acad\u00e8mic va explicar com l’epigen\u00e8tica ha experimentat un ressorgiment els darrers anys gr\u00e0cies al paper que ha cobrat en la detecci\u00f3 de malalties i el desenvolupament de ter\u00e0pies. “Part del renaixement de l’epigen\u00e8tica \u00e9s degut a l’exist\u00e8ncia de tests basats en els seus marcadors per detectar certes malalties com el c\u00e0ncer o determinar l’edat biol\u00f2gica d’un individu. Per\u00f2 el pas clau ha estat segurament l’aprovaci\u00f3 de diversos f\u00e0rmacs epigen\u00e8tics per tractar-ne diverses patologies neopl\u00e0siques. Un \u00e8xit que ha estat fruit de l’esfor\u00e7 de diverses generacions de cient\u00edfics, des de bioqu\u00edmics fins a bi\u00f2legs estructurals fins a investigadors translacionals i cl\u00ednics. Si \u00e9s una disciplina fosca, l’epigen\u00e8tica s’ha convertit en el focus de recerca de nombrosos grups de recerca al m\u00f3n”, va iniciar Esteller la seva intervenci\u00f3.<\/p>\n
Esteller va abordar el c\u00e0ncer com un exemple de malaltia en qu\u00e8 l’epigen\u00e8tica juga un paper important. Per aix\u00f2 va introduir el concepte de metilaci\u00f3, una reacci\u00f3 qu\u00edmica al cos per la qual una mol\u00e8cula petita que s’anomena grup metil s’uneix a l’ADN, prote\u00efnes o altres mol\u00e8cules. La metilaci\u00f3 de l’ADN al c\u00e0ncer pot afectar la regulaci\u00f3 de gens i causar expressi\u00f3 inapropiada de gens espec\u00edfics de teixit. Aquesta metilaci\u00f3 aberrant pot comen\u00e7ar a zones normals d’interacci\u00f3 de l’ADN i estendre’s a altres regions amb l’ajuda de factors oncog\u00e8nics que poden atreure els enzims de metilaci\u00f3 a llocs incorrectes. L’expert tamb\u00e9 va explicar que la hipermetilaci\u00f3 de gens supressors de tumors i gens de reparaci\u00f3 de l’ADN \u00e9s com\u00fa en el c\u00e0ncer, i que la metilaci\u00f3 de l’ADN s’ha convertit en una eina \u00fatil per al diagn\u00f2stic i el pron\u00f2stic d’aquesta malaltia. Tamb\u00e9 es va referir a la investigaci\u00f3 de l’epigen\u00e8tica en altres malalties com ara malalties cardiovasculars.<\/p>\n
![\"\"](\"https:\/\/raed.academy\/wp-content\/uploads\/2023\/09\/epigenetica-y-cancer-manel-esteller-investigacion-ADN-medicina.webp\")
El recipiendari va assegurar que les vies de recerca es continuen desenvolupant i va augurar resultats fruct\u00edfers en la lluita contra el c\u00e0ncer. “Crec que hi ha dos camps de recerca que acoblats a l’epigen\u00e8tica proporcionaran resultats valuosos per a la recerca b\u00e0sica, translacional i cl\u00ednica. El primer \u00e9s la irrupci\u00f3 de les tecnologies per dur a terme an\u00e0lisis de c\u00e8l\u00b7lula \u00fanica que a m\u00e9s ara tamb\u00e9 es poden desenvolupar en l’\u00e0mbit espacial. La possibilitat de contemplar alhora la totalitat de la metilaci\u00f3 de l’ADN, les modificacions d’histones i el posicionament dels nucleosomes de forma din\u00e0mica a cada c\u00e8l\u00b7lula solit\u00e0ria \u00e9s molt excitant, no nom\u00e9s per comprendre els \u00faltims engranatges d’aquestes capes de regulaci\u00f3. gen\u00e8tica, sin\u00f3 tamb\u00e9 per plantejar-nos el seu \u00fas cl\u00ednic, com per exemple en l’avaluaci\u00f3 de la malaltia m\u00ednima residual i el segon camp que permetr\u00e0 cr\u00e9ixer l’epigen\u00e8tica \u00e9s la seva disciplina filla: la epitranscript\u00f2mica, que estudia les modificacions de l’ARN, que s\u00f3n moltes i riques, i les diferents modificacions que formen el codi d’histones. I el primer f\u00e0rmac epitranscript\u00f2mic ha debutat en un assaig cl\u00ednic en oncologia\u2026 Gaudim d’aquest nou viatge del coneixement”, va concloure.<\/p>\n
Catedr\u00e0tic de Gen\u00e8tica a la Facultat de Medicina de la Universitat de Barcelona<\/strong>, Esteller dirigeix actualment l’Institut de Recerca contra la Leuc\u00e8mia Josep Carreras<\/strong> de Barcelona despr\u00e9s d’haver liderat el Programa d’Epigen\u00e8tica i Biologia del C\u00e0ncer<\/strong> de l’Institut de Recerca Biom\u00e8dica de Bellvitge<\/strong>. Entre altres guardons, ha rebut el Premi Carmen i Severo Ochoa de Recerca en Biologia Molecular<\/strong>, el Premi Nacional de Gen\u00e8tica<\/strong>, el Premi Rei Jaume I<\/strong>, el Premi Nacional de Recerca<\/strong> de la Generalitat de Catalunya<\/strong> i el Premi Internacional Catalunya<\/strong>. \u00c9s autor de m\u00e9s de 600 publicacions i la Universitat de Stanford<\/strong> ho considera un dels cient\u00edfics m\u00e9s citats a escala mundial.<\/p>\n[\/et_pb_text][et_pb_divider show_divider=”off” _builder_version=”4.22.2″ _module_preset=”default” custom_padding=”25px||||false|false” global_colors_info=”{}”][\/et_pb_divider][et_pb_video src=”https:\/\/youtu.be\/HOGQUrD-G4s” _builder_version=”4.22.2″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_video][et_pb_divider show_divider=”off” _builder_version=”4.22.2″ _module_preset=”default” custom_padding=”25px||||false|false” global_colors_info=”{}”][\/et_pb_divider][et_pb_gallery gallery_ids=”137869,137872,137875,137878,137881,137884,137887,137890,137893,137896,137899,137902″ posts_number=”16″ show_title_and_caption=”off” show_pagination=”off” admin_label=”Galer\u00eda” module_class=”galeria-pad-1″ _builder_version=”4.22.2″ _module_preset=”default” locked=”off” global_colors_info=”{}”][\/et_pb_gallery][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"
Manel Esteller aborda el c\u00e0ncer des del paper rellevant que hi juga l’epigen\u00e8tica, al seu discurs d’ingr\u00e9s a la RAED: “Una visi\u00f3n personal de la epigen\u00e9tica: de la biolog\u00eda a la aplicaci\u00f3n m\u00e9dica”<\/p>\n","protected":false},"author":12,"featured_media":137971,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"Manuel Esteller<\/strong>, doctor en Medicina i Cirurgia, va ingressar com a acad\u00e8mic de n\u00famero de la Reial Acad\u00e8mia Europea de Doctors-Barcelona 1914<\/strong> (RAED) durant una solemne sessi\u00f3 que es va celebrar a la Sala d'Actes de Foment del Treball<\/strong>, seu de la Reial Corporaci\u00f3, el 28 de setembre passat. L'acte es va poder seguir tant de forma presencial com en streaming a trav\u00e9s del canal de YouTube<\/strong> de la RAED, on es pot visionar. El recipienari va llegir el discurs d'ingr\u00e9s \"Una visi\u00f3n personal de la epigen\u00e9tica: de la biolog\u00eda a la aplicaci\u00f3n m\u00e9dica\"<\/strong>, on explica el cam\u00ed que ell mateix ha transitat al llarg de la seva reconeguda carrera cient\u00edfica per convertir-se en un dels referents internacionals a epigen\u00e8tica i en la investigaci\u00f3 del c\u00e0ncer. Li va respondre, en nom de la Reial Acad\u00e8mia, l'acad\u00e8mica numer\u00e0ria Carol Moreno<\/strong><\/em><\/a>.\r\n\r\nEl nou acad\u00e8mic va explicar com l'epigen\u00e8tica ha experimentat un ressorgiment els darrers anys gr\u00e0cies al paper que ha cobrat en la detecci\u00f3 de malalties i el desenvolupament de ter\u00e0pies. \"Part del renaixement de l'epigen\u00e8tica \u00e9s degut a l'exist\u00e8ncia de tests basats en els seus marcadors per detectar certes malalties com el c\u00e0ncer o determinar l'edat biol\u00f2gica d'un individu. Per\u00f2 el pas clau ha estat segurament l'aprovaci\u00f3 de diversos f\u00e0rmacs epigen\u00e8tics per tractar-ne diverses patologies neopl\u00e0siques Un \u00e8xit que ha estat fruit de l'esfor\u00e7 de diverses generacions de cient\u00edfics, des de bioqu\u00edmics fins a bi\u00f2legs estructurals fins a investigadors translacionals i cl\u00ednics. Si \u00e9s una disciplina fosca, l'epigen\u00e8tica s'ha convertit en el focus de recerca de nombrosos grups de recerca al m\u00f3n\", va iniciar Esteller la seva intervenci\u00f3.\r\n\r\nEsteller va posar el c\u00e0ncer \u00e9s abordat com un exemple de malaltia en qu\u00e8 l'epigen\u00e8tica juga un paper important. Per aix\u00f2 va introduir el concepte de metilaci\u00f3, una reacci\u00f3 qu\u00edmica al cos per la qual una mol\u00e8cula petita que s'anomena grup metil s'uneix a l'ADN, prote\u00efnes o altres mol\u00e8cules. La metilaci\u00f3 de l'ADN al c\u00e0ncer pot afectar la regulaci\u00f3 de gens i causar expressi\u00f3 inapropiada de gens espec\u00edfics de teixit. Aquesta metilaci\u00f3 aberrant pot comen\u00e7ar a zones normals d'interacci\u00f3 de l'ADN i estendre's a altres regions amb l'ajuda de factors oncog\u00e8nics que poden atreure els enzims de metilaci\u00f3 a llocs incorrectes. L'expert tamb\u00e9 va explicar que la hipermetilaci\u00f3 de gens supressors de tumors i gens de reparaci\u00f3 de l'ADN \u00e9s com\u00fa en el c\u00e0ncer, i que la metilaci\u00f3 de l'ADN s'ha convertit en una eina \u00fatil per al diagn\u00f2stic i el pron\u00f2stic d'aquesta malaltia. Tamb\u00e9 es va referir a la investigaci\u00f3 de l'epigen\u00e8tica en altres malalties com ara malalties cardiovasculars.\r\n\r\nEl recipientari va assegurar que les vies de recerca es continuen desenvolupant i va augurar resultats fruct\u00edfers en la lluita contra el c\u00e0ncer. \"Crec que hi ha dos camps de recerca que acoblats a l'epigen\u00e8tica proporcionaran resultats valuosos per a la recerca b\u00e0sica, translacional i cl\u00ednica. El primer \u00e9s la irrupci\u00f3 de les tecnologies per realitzar an\u00e0lisi de c\u00e8l\u00b7lula \u00fanica que a m\u00e9s ara tamb\u00e9 es poden desenvolupar a nivell espacial La possibilitat de contemplar alhora la totalitat de la metilaci\u00f3 de l'ADN, les modificacions d'histones i el posicionament dels nucleosomes de forma din\u00e0mica a cada c\u00e8l\u00b7lula solit\u00e0ria \u00e9s molt excitant, no nom\u00e9s per comprendre els \u00faltims engranatges d'aquestes capes de regulaci\u00f3. gen\u00e8tica, sin\u00f3 tamb\u00e9 per plantejar-nos el seu \u00fas cl\u00ednic, com per exemple en l'avaluaci\u00f3 de la malaltia m\u00ednima residual i el segon camp que permetr\u00e0 cr\u00e9ixer l'epigen\u00e8tica \u00e9s la seva disciplina filla: la\r\nepitranscript\u00f2mica, que estudia les modificacions de l'ARN, que s\u00f3n moltes i riques, i les diferents modificacions que formen el codi d'histones. I el primer f\u00e0rmac epitranscript\u00f2mic ha debutat en un assaig cl\u00ednic en oncologia\u2026 Gaudim d'aquest nou viatge del coneixement\", va concloure.\r\n\r\nCatedr\u00e0tic de Gen\u00e8tica a la Facultat de Medicina de la Universitat de Barcelona<\/strong>, Esteller dirigeix actualment l'Institut de Recerca contra la Leuc\u00e8mia Josep Carreras<\/strong> de Barcelona despr\u00e9s d'haver liderat el Programa d'Epigen\u00e8tica i Biologia del C\u00e0ncer<\/strong> de l'Institut de Recerca Biom\u00e8dica de Bellvitge<\/strong>. Entre altres guardons, ha rebut el Premi Carmen i Severo Ochoa de Recerca en Biologia Molecular<\/strong>, el Premi Nacional de Gen\u00e8tica<\/strong>, el Premi Rei Jaume I<\/strong>, el Premi Nacional de Recerca<\/strong> de la Generalitat de Catalunya<\/strong> i el Premi Internacional Catalunya<\/strong>. \u00c9s autor de m\u00e9s de 600 publicacions i la Universitat de Stanford<\/strong> ho considera un dels cient\u00edfics m\u00e9s citats a nivell mundial.","_et_gb_content_width":"","footnotes":""},"categories":[332,455,442],"tags":[],"class_list":["post-137633","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biologia-ca","category-ciencies-de-la-salut","category-ciencies-farmaceutiques-ciencies-de-la-salut","et-has-post-format-content","et_post_format-et-post-format-standard"],"yoast_head":"\nL'epigen\u00e8tica, \u00faltima frontera en la lluita contra el c\u00e0ncer - Reial Acad\u00e8mia Europea de Doctors<\/title>\n<meta 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