{"id":134274,"date":"2023-06-15T08:56:54","date_gmt":"2023-06-15T08:56:54","guid":{"rendered":"https:\/\/raed.academy\/?p=134274"},"modified":"2023-06-15T10:10:03","modified_gmt":"2023-06-15T10:10:03","slug":"genetica-i-envelliment","status":"publish","type":"post","link":"https:\/\/raed.academy\/ca\/genetica-i-envelliment\/","title":{"rendered":"Gen\u00e8tica i envelliment"},"content":{"rendered":"
\"August

Dr. August Corominas<\/p><\/div>\n

August Corominas<\/strong><\/em><\/a>, professor de Fisiologia Humana de la Universitat de M\u00farcia<\/strong> i de la Universitat Aut\u00f2noma de Barcelona<\/strong> i acad\u00e8mic em\u00e8rit i membre del Senat<\/strong> de la Reial Acad\u00e8mia Europea de Doctors-Barcelona 1914<\/strong> (RAED), comparteix amb la comunitat acad\u00e8mica l’article “\u00c9s possible arribar als cent anys o fins i tot m\u00e9s enll\u00e0?”<\/strong>. Endinsant-se en aquesta mateixa mat\u00e8ria, l’acad\u00e8mic va compartir recentment en aquesta publicaci\u00f3 els articles “Els quatre genets de l’apocalipsi gerontol\u00f2gic: solitud, silenci, dolor i nocturnitat”<\/strong><\/a>, “Reflexi\u00f3 antropol\u00f2gica de l’edat centen\u00e0ria”<\/strong><\/a>, “D’avis a n\u00e9ts”<\/strong><\/a>, “\u00c9s possible arribar als cent anys o fins i tot m\u00e9s enll\u00e0?”<\/strong><\/a> i “Mecanismes de tanatoqu\u00edmica i tanatof\u00edcs en el proc\u00e9s de la mort”<\/strong><\/a>. A m\u00e9s \u00e9s autor d’un dels cap\u00edtols del llibre “Vitalidad al envejecer. Si lo deseas, puedes vivir m\u00e1s a\u00f1os con salud”<\/strong>, editat per la Reial Corporaci\u00f3 amb el suport de Vichy Catal\u00e1n<\/strong>.<\/p>\n

Gen\u00e8tica i envelliment. Prog\u00e8ria i s\u00edndromes progeroides<\/h2>\n

La gen\u00e8tica \u00e9s un factor important (25%) en el proc\u00e9s d’envelliment. Algunes persones tenen una certa susceptibilitat gen\u00e8tica que influeix molt m\u00e9s intensament que el col\u00b7lectiu mitj\u00e0. Hi ha efecte negatiu d’alguns gens (gerontogens, tanat\u00f2gens o gens deleteris). Altres gens tenen efectes positius, s\u00f3n els gens protectors o gens de longevitat. Hi ha alguns gens en col\u00b7lectius tancats que protegeixen contra envelliment i permeten viure uns deu anys m\u00e9s que en la mitjana normal de la longevitat mitjana. Tenim dos bons exemples al col\u00b7lectiu jueu de Malta i al grup amish d’Oregon.<\/p>\n

\"\"S’ha descrit que les c\u00e8l\u00b7lules viuen fins a un nombre de cronomitosis, fins a l’anomenat l\u00edmit de Hayflick. Un dels mecanismes biol\u00f2gics que explica aquest fenomen \u00e9s l’escur\u00e7ament dels tel\u00f2mers, que s\u00f3n formacions d’ADN que apareixen als extrems dels cromosomes. Els tel\u00f2mers s’escurcen irreversiblement amb el pas del temps a cada cicle de la divisi\u00f3 cel\u00b7lular, per acci\u00f3 de la telomerasa. Quan els tel\u00f2mers es fan molt curts, les c\u00e8l\u00b7lules perden la capacitat de dividir-se. Algunes c\u00e8l\u00b7lules (epiteli intestinal, fibroblasts de la pell) no s\u00f3n capaces de sobrepassar el l\u00edmit de les 50 divisions.<\/p>\n

La mort cel\u00b7lular ocorre per necrosi o apoptosi. La necrosi ocorre en resposta per un insult f\u00edsic o qu\u00edmic. L’apoptosi \u00e9s un proc\u00e9s molt regulat ordenat mitjan\u00e7ant la qual la c\u00e8l\u00b7lula \u00e9s indu\u00efda a una mena de su\u00efcidi.<\/p>\n

La prog\u00e8ria o s\u00edndrome de Hutchinson-Gilford \u00e9s un fenomen poc freq\u00fcent (1\/8.000.000 nascuts). Consisteix en l’aparici\u00f3 de signes d’envelliment en nens entre el primer i el segon any de vida. La majoria dels casos de prog\u00e8ria s\u00f3n espor\u00e0dics, cosa que planteja la possibilitat d’un patr\u00f3 d’her\u00e8ncia autos\u00f2mic dominant per mutaci\u00f3 de novo. El diagn\u00f2stic diferencial d’aquesta entitat s’ha de plantejar amb qualsevol de les altres s\u00edndromes progeroides descrites a la literatura. Es presenta una revisi\u00f3 actualitzada sobre el tema fent \u00e8mfasi en l’aproximaci\u00f3 diagn\u00f2stica del quadre.<\/p>\n","protected":false},"excerpt":{"rendered":"

August Corominas comparteix amb la comunitat acad\u00e8mica l’article “Gen\u00e8tica i envelliment. Prog\u00e8ria i s\u00edndromes progeroides”<\/p>\n","protected":false},"author":12,"featured_media":134192,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"categories":[455,213],"tags":[],"class_list":["post-134274","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ciencies-de-la-salut","category-medicina-i-cirurgia","et-has-post-format-content","et_post_format-et-post-format-standard"],"yoast_head":"\nGen\u00e8tica i envelliment - Reial Acad\u00e8mia Europea de Doctors<\/title>\n<meta name=\"description\" content=\"August Corominas comparteix amb la comunitat acad\u00e8mica l'article "Gen\u00e8tica i envelliment. 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